N-(3,4-dichlorophenyl)hexanamide synthesis

Yield:2533-89-3 62%

Reaction Conditions:

Stage #1: 2-Methylpentanoic acidwith benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide; for 0.166667 h;
Stage #2: m,p-dichloroaniline in N,N-dimethyl-formamide at 20 - 25; for 16 h;

References:

Arenz, Christoph;Basu, Shibom;Bechara, Cherine;Bossis, Guillaume;Cong, Xiaojing;Del Nero, Elise;Drapeau, Marion;Fontanel, Simon;Gabellier, Ludovic;Golebiowski, Jér?me;Granier, Sebastien;Healey, Robert D.;Hornemann, Thorsten;Jeannot, Sylvain;Karsai, Gergely;Leyrat, Cedric;Maurel, Damien;Saied, Essa M.;Saint-Paul, Julie [Angewandte Chemie - International Edition,2022,vol. 61,# 2,art. no. E202109967][Angew. Chem.,2022,vol. 134,# 2,p. 11111 - 11118] Location in patent:supporting information