N-(3,5-Dichlorophenyl)benzenesulfonaMide, 97% synthesis
- Product Name:N-(3,5-Dichlorophenyl)benzenesulfonaMide, 97%
- CAS Number:54129-15-6
- Molecular formula:C12H9Cl2NO2S
- Molecular Weight:302.18
98-09-9
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$12.00/25g
626-43-7
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54129-15-6
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$159.00/50MG
Yield:54129-15-6 51%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 48 h;
Steps:
4.12.a
Benzenesulfonyl chloride (1.74 mL, 13.57 mmol) and DIEA (0.34 mL, 2.49 mmol) were added to a solution of 3,5-dichloroaniline (2.0 g, 12.34 mmol) in DCM (50 mL). The resulting solution was stirred at room temperature for 48 h, during which a precipitate was formed. The reaction mixture was then evaporated to dryness and purified by flash column chromatography (ethyl acetate/hexanes = 1/9) to give TC-IV-145 (1.90 g, 51%) as a yellow solid.
References:
WO2010/59241,2010,A2 Location in patent:Page/Page column 118