![](/CAS/20150408/GIF/53186-44-0.gif)
N-(3-AMinopropyl)acetaMide HCl synthesis
- Product Name:N-(3-AMinopropyl)acetaMide HCl
- CAS Number:53186-44-0
- Molecular formula:C5H13ClN2O
- Molecular Weight:152.6225
![Carbamic acid, N-[3-(acetylamino)propyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/1041345-05-4.gif)
1041345-05-4
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![N-(3-AMinopropyl)acetaMide HCl](/CAS/20150408/GIF/53186-44-0.gif)
53186-44-0
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$184.00/1g
Yield:53186-44-0 100%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 72 h;
Steps:
Intermediate 74: N-(3-azaniumylpropyl)acetamide chloride
4 N HC1 in 1,4-Dioxane (11.44 mL, 45.77 mmol) was added dropwise to an ice cooled solution of Intermediate 73 (1.1 g, 5.09 mmol) in 1,4-Dioxane (8 mL). The mixture was stirred at RT 72 hrs, then volatiles were removed under vacuum to afford Intermediate 74 (990 mg, recovery assumed quantitative). (0479) 1H NMR (400 MHz, DMSO-d6 ) δ ppm 7.87 - 8.14 (m, 4 H), 3.09 (q, J= 6.60 Hz, 2 H), 2.71 - 2.84 (m, 2 H), 1.82 (s, 3 H), 1.63 - 1.73 (m, 2 H).
References:
WO2022/13307,2022,A1 Location in patent:Page/Page column 113
![Acetic anhydride](/CAS/20180808/GIF/108-24-7.gif)
108-24-7
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![1,3-Diaminopropane](/CAS/GIF/109-76-2.gif)
109-76-2
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![N-(3-AMinopropyl)acetaMide HCl](/CAS/20150408/GIF/53186-44-0.gif)
53186-44-0
17 suppliers
$184.00/1g