ChemicalBook CAS DataBase List N-(3-AMinopropyl)acetaMide HCl

N-(3-AMinopropyl)acetaMide HCl synthesis

2synthesis methods

Product Name:N-(3-AMinopropyl)acetaMide HCl
CAS Number:53186-44-0
Molecular formula:C5H13ClN2O
Molecular Weight:152.6225

Carbamic acid, N-[3-(acetylamino)propyl]-, 1,1-dimethylethyl ester

1041345-05-4
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53186-44-0
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Yield:53186-44-0 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 72 h;

Steps:

Intermediate 74: N-(3-azaniumylpropyl)acetamide chloride

4 N HC1 in 1,4-Dioxane (11.44 mL, 45.77 mmol) was added dropwise to an ice cooled solution of Intermediate 73 (1.1 g, 5.09 mmol) in 1,4-Dioxane (8 mL). The mixture was stirred at RT 72 hrs, then volatiles were removed under vacuum to afford Intermediate 74 (990 mg, recovery assumed quantitative). (0479) ¹H NMR (400 MHz, DMSO-d₆ ) δ ppm 7.87 - 8.14 (m, 4 H), 3.09 (q, J= 6.60 Hz, 2 H), 2.71 - 2.84 (m, 2 H), 1.82 (s, 3 H), 1.63 - 1.73 (m, 2 H).

References:

WO2022/13307,2022,A1 Location in patent:Page/Page column 113

108-24-7
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109-76-2 Synthesis

109-76-2
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53186-44-0
17 suppliers
$184.00/1g

References