ChemicalBook CAS DataBase List N-(3-ETHYNYLPHENYL)ACETAMIDE

N-(3-ETHYNYLPHENYL)ACETAMIDE synthesis

5synthesis methods

Product Name:N-(3-ETHYNYLPHENYL)ACETAMIDE
CAS Number:70933-58-3
Molecular formula:C10H9NO
Molecular Weight:159.18

54060-30-9 Synthesis

54060-30-9
514 suppliers
$8.00/5g

75-05-8 Synthesis

75-05-8
967 suppliers
$10.00/10g

70933-58-3
48 suppliers
$45.00/50mg

Yield: 77%

Reaction Conditions:

Stage #1:3-acetylenephenylamine with tetrafluoroboric acid in waterInert atmosphere;
Stage #2:acetonitrile with potassium phosphate;water at 80; for 12 h;

Steps:

General procedure
General procedure: A mixture of aryl diazonium tetrafluoroborates compounds (0.5 mmol), nitriles (0.5 mmol), H₂O (1.5 mmol) and K₃PO₄(0.6 mmol) was dissolved in acetonitrile (1.0 mL) or ethyl acetate (1.0 mL) under N₂ atmosphere, stirred at 80 ^oC for 12h. Removal of the solvent under a reduced pressure gave the crude product; pure product was obtained by passing the crude product through a short silica gel column using Hexane/EtOAc (1:1-2:1) as eluent.

References:

Xiong, Biquan;Wang, Gang;Xiong, Tao;Wan, Liming;Zhou, Congshan;Liu, Yu;Zhang, Panliang;Yang, Changan;Tang, Kewen [Tetrahedron Letters,2018,vol. 59,# 32,p. 3139 - 3142] Location in patent:supporting information

54060-30-9 Synthesis

54060-30-9
514 suppliers
$8.00/5g

75-36-5 Synthesis