ChemicalBook CAS DataBase List N-(3-FORMYLPHENYL)METHANESULFONAMIDE

N-(3-FORMYLPHENYL)METHANESULFONAMIDE synthesis

5synthesis methods

Product Name:N-(3-FORMYLPHENYL)METHANESULFONAMIDE
CAS Number:55512-05-5
Molecular formula:C8H9NO3S
Molecular Weight:199.23

376347-09-0 Synthesis

N-(3-(HYDROXYMETHYL)PHENYL)METHANESULFONAMIDE

376347-09-0
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55512-05-5
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Yield:55512-05-5 97%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane at 20; for 1 h;

Steps:

5.1.77.C

C. 3-[(MethyIsulfonyl)amino]benzaldehyde.; [3-(Hydroxymethyl) phenyl](methylsulfonyl) amine (0.42 g, 2.08 mmol) was dissolved in dichloromethane (20 mL) followed by addition of pyridinium chlorochromate (0.67 g, 3.12 mmol). The reaction was stirred at rt for IH. Filtered crude reaction through a plug of silica gel and washed with 60% EtOAc/Hex (250 mL), removed volatiles under reduced pressure to afford the title compound (0.40 g, 2.01 mmol, 97%) as a white solid. MS (ESI) m/z 200.2 [M+l]⁺ [00391]

References:

WO2008/51494,2008,A1 Location in patent:Page/Page column 119