N-(4-AMINOPHENYL)-3-METHYLBENZAMIDE synthesis

6synthesis methods

Product Name:N-(4-AMINOPHENYL)-3-METHYLBENZAMIDE
CAS Number:425651-25-8
Molecular formula:C14H14N2O
Molecular Weight:226.27

73230-98-5
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425651-25-8
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$45.00/10mg

Yield:425651-25-8 85.2%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water; for 2 h;Reflux;

Steps:

16.2 2. Preparation of 3-methyl-N-(4-aminophenyl)benzamide (11j)

Compound 10j was dissolved in EtOH (20 ml), and an aqueous solution of iron powder (2.5 g) and ammonium chloride (0.53 g, 10 mmol) was added and the reaction was refluxed for 2 hours. Followed by hot filter, collected filtrate spin dry. The resulting solid was dissolved in acetone and the filtrate was collected by filtration and the solution was dried to give compound 11j in 85.2% yield.

References:

CN106699755,2017,A Location in patent:Paragraph 0105; 0285; 0286

99-04-7 Synthesis