ChemicalBook CAS DataBase List N-(4-Chlorophenyl)-4-MethylbenzaMide, 97%

N-(4-Chlorophenyl)-4-MethylbenzaMide, 97% synthesis

13synthesis methods

Product Name:N-(4-Chlorophenyl)-4-MethylbenzaMide, 97%
CAS Number:33667-89-9
Molecular formula:C14H12ClNO
Molecular Weight:245.7

404-25-1 Synthesis

AcetaMide, N-(4-chlorophenyl)-2,2,2-trifluoro-

404-25-1
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N-(4-Chlorophenyl)-4-MethylbenzaMide, 97%

33667-89-9
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$28.60/50MG

Yield:33667-89-9 85%

Reaction Conditions:

in toluene at 70; for 24 h;Inert atmosphere;

Steps:

8 Preparation Example 8

Add a magnetic stirrer to the 10 mL reaction tube,0.3 mmol of 1-trifluoroacetyl-4-chloroaniline (R1=CF3, R2=4-Cl-Ph), and vacuum-filled with nitrogen three times.1 mL of anhydrous toluene, 0.9 mmol of p-tolylmagnesium bromide was added under a nitrogen atmosphere, and the reaction was carried out at 70 ° C for 24 hours.After the reaction is completed, it is quenched by adding saturated brine, extracted, dried, and concentrated.The (4-tolylcarboxamido)-4-chloroaniline was isolated by column chromatography in a yield of 85%.

References:

CN108516957,2018,A Location in patent:Paragraph 0029-0030

1679-18-1 Synthesis