N-(4-Fluorobenzyl)-2-iodoaniline, 97% 97% synthesis
- Product Name:N-(4-Fluorobenzyl)-2-iodoaniline, 97% 97%
- CAS Number:1040308-57-3
- Molecular formula:C13H11FIN
- Molecular Weight:327.14
Yield:1040308-57-3 84%
Reaction Conditions:
with sodium hydrogencarbonate in N,N-dimethyl-formamide at 50;
Steps:
General procedure: An oven-dried flask was charged with o-iodoaniline (13 mmol), the corresponding benzyl bromide(10 mmol), NaHCO3 (20 mmol), and DMF (20 mL). The mixture was stirred at 50 °C under air for 3-4 h.After the completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambienttemperature and 15 mL water was added to the mixture, then extracted by EtOAc for 3 times (3 × 30 mL).The combined extracts were washed with brine, dried over Na2SO4, and the solvent was removed in vacuoto provide a crude product, which was purified by column chromatography on silica gel to afford pure product.
References:
Chen, Zhengkai;Li, Hongli;Cao, Gangjian;Xu, Jianfeng;Miao, Maozhong;Ren, Hongjun [Synlett,2017,vol. 28,# 4,art. no. ST-2016-W0584-L,p. 504 - 508] Location in patent:supporting information
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