N-(4-methoxyphenyl)-N'-(2-thienylcarbonyl)thiourea synthesis
- Product Name:N-(4-methoxyphenyl)-N'-(2-thienylcarbonyl)thiourea
- CAS Number:352348-63-1
- Molecular formula:C13H12N2O2S2
- Molecular Weight:292.3766
Yield:352348-63-1 78%
Reaction Conditions:
at 27; for 2 h;
Steps:
2.3. General procedure for synthesis of compounds (1-8)
General procedure: A solution of thiophene-2-carbonyl chloride (1.06 mmol,10 mmol) in dry acetone (30 mL) was mixed to a suspension of ammonium thiocyanate (0.78 g, 10 mmol) in dry acetone (30 mL)and was heated (60 °C) under reflux for 1 h. The resultant thiophene-2-carbonyl isothiocyanate solution was treated with equimolar quantity of appropriate substituted aromatic primary aminein acetone (Scheme 1) and further refluxed for 2 h at 27 °C [30,31,33e35]. The precipitated ammonium chloride was filtered off and the yellow colour solution was evaporated in vacuum to dryness to obtain crude crystalline product. Yellow crystals of the compound 1 were grown by the slow evaporation of its solution inacetone/dichloromethane (1:1) in one week at 20 °C.
References:
Pandey, Sunil K.;Pratap, Seema;Marverti, Gaetano;Kaur, Manpreet;Jasinski, Jerry P. [Journal of Molecular Structure,2019,vol. 1180,p. 447 - 454]
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