N-(4-METHYLBENZYL)UREA synthesis

8synthesis methods

Product Name:N-(4-METHYLBENZYL)UREA
CAS Number:54582-34-2
Molecular formula:C9H12N2O
Molecular Weight:164.2

98952-71-7
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$189.00/500mg

54582-34-2
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$45.00/100mg

Yield:54582-34-2 83%

Reaction Conditions:

with Acetaldehyde oxime;cerium(IV) oxide in ethanol; for 2 h;Reflux;Inert atmosphere;

Steps:

Hydration of cyanamides using acetaldoxime and nano cerium oxide as a reusable heterogeneous catalyst; general procedure

General procedure: Cyanamide (1.0 mmol), acetaldoxime (2.0 mmol), nano cerium oxide (5.0 mol%) and EtOH (5 mL) were added to a 25 mL roundbottom flask equipped with magnetic stirrer. The mixture was heated to reflux under a nitrogen atmosphere for 2 h. After cooling to room temperature, the solid was filtered, washed with EtOH and the filtrate evaporated. The filtered catalyst can be recycled after washing with CH2Cl2and drying for 2 h. The crude product was purified by column chromatography. All the isolated compounds were characterised by m.p., IR, 1H NMR, 13C NMR and elemental analysis. The physical data (m.p., IR, NMR) of known compounds were found to be identical with those reported in the literature.

References:

Sajadi, S. Mohammad;Maham, Mehdi [Journal of Chemical Research,2013,vol. 37,# 10,p. 623 - 625]

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