N-(6-Methoxy-4-Methylpyridin-3-yl)acetaMide synthesis
- Product Name:N-(6-Methoxy-4-Methylpyridin-3-yl)acetaMide
- CAS Number:76013-32-6
- Molecular formula:C9H12N2O2
- Molecular Weight:180.2
6635-91-2
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Yield:76013-32-6 100%
Reaction Conditions:
in toluene at 100; for 2 h;
Steps:
122 Example 122: Preparation of N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)-l- ((3- chloroquinolin-6-yl)methyl)-5-methoxy-lH-pyrazolo[3,4-c]pyridine-3-carboxamide
To a solution of 6-methoxy-4-methylpyridin-3-amine (5.0 g, 36.2 mmol, 1.0 eq) in toluene (100.0 mL), was added acetic anhydride (5.2 g, 50.7 mmol, 1.4 eq). The mixture was stirred and heated at 100 °C for 2 h, then cooled. The solvent of the mixture was removed in vacuo to provide N-(6-methoxy-4-methylpyridin-3-yl)acetamide (6.5 g, 100%).
References:
WO2018/11628,2018,A1 Location in patent:Paragraph 00631