N-Benzyl-1-aminoadamantane synthesis
- Product Name:N-Benzyl-1-aminoadamantane
- CAS Number:3717-60-0
- Molecular formula:C17H23N
- Molecular Weight:241.37
Yield:3717-60-0 100%
Reaction Conditions:
with acetic acid in methanol at 20; for 48 h;
Steps:
1 Process A
General procedure: Process A
The 1-aminoadamantane and 2-aminoadamantane derivatives of general formula (Ia) as described above and which appear, respectively, in tables A1 and A2 are prepared as follows: a suspension, in methanol, of 1-adamantylamine or 2-adamantylamine (0.5 mmol; 75 mg; 1 equiv.) is added, with stirring, to an aromatic aldehyde (1 equiv.) according to the compound to be prepared, in the presence of BH3CN on resin (0.75 mmol; 1.5 equiv.) and of acetic acid (1.5 mmol; 84 μl; 3 equiv.). The whole is stirred for 2 days at ambient temperature, filtered, washed with methanol, evaporated and then purified.
Tables A1 and A2 give the number of the compound, the aldehyde used, the name of the compound obtained, the characteristics of the compound and also the code of the purification method used, the appearance of the compound obtained and its yield.
References:
US2016/83355,2016,A1 Location in patent:Paragraph 0175; 0176
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