N-benzyl-2-bromothiazol-4-carboxamide synthesis
- Product Name:N-benzyl-2-bromothiazol-4-carboxamide
- CAS Number:1449218-23-8
- Molecular formula:C11H9BrN2OS
- Molecular Weight:297.17
5198-88-9
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Yield:1449218-23-8 73%
Reaction Conditions:
Stage #1: 2-bromothiazole-4-carboxylic Acidwith benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in tetrahydrofuran at 20; for 0.5 h;
Stage #2: benzylamine in tetrahydrofuran at 20; for 18 h;
References:
Ries, Oliver;Granitzka, Markus;Stalke, Dietmar;Ducho, Christian [Synthetic Communications,2013,vol. 43,# 21,p. 2876 - 2882]