N-Benzyl-4,6-difluoropyrimidin-2-amine synthesis
1synthesis methods
- Product Name:N-Benzyl-4,6-difluoropyrimidin-2-amine
- CAS Number:130866-84-1
- Molecular formula:C11H9F2N3
- Molecular Weight:221.21
Yield:-
Reaction Conditions:
in diethyl ether;
Steps:
12 Preparation of 2-benzylamino-4,6-difluoropyrimidine (Variant A) STR20
EXAMPLE 12 Preparation of 2-benzylamino-4,6-difluoropyrimidine (Variant A) STR20 23.5 g (0.22 mol) of benzylamine were added at -20 C. to a stirred mixture of 13.4 9 (0.1 mol) of 2,4,6-trifluoropyrimidine in 150 ml of diethyl ether within 15 min, and the mixture was stirred at this temperature for 1 hour. After a further hour at 25° C., working up was carried out as in Example 10. 21.4 g (98% of theory) of the title compound of melting point 70°-73° C. were obtained in this way.
References:
US5011927,1991,A