ChemicalBook CAS DataBase List N-BENZYLAMINOACETONITRILE HYDROCHLORIDE

N-BENZYLAMINOACETONITRILE HYDROCHLORIDE synthesis

4synthesis methods

Product Name:N-BENZYLAMINOACETONITRILE HYDROCHLORIDE
CAS Number:63086-36-2
Molecular formula:C9H11ClN2
Molecular Weight:182.65

107-14-2 Synthesis

107-14-2
284 suppliers
$15.00/25g

100-46-9 Synthesis

100-46-9
487 suppliers
$5.00/5G

63086-36-2
23 suppliers
$44.89/5g

Yield:63086-36-2 92%

Reaction Conditions:

Stage #1: chloroacetonitrile;benzylaminewith potassium carbonate;sodium iodide in acetonitrile at 80; for 18 h;
Stage #2: with hydrogenchloride in diethyl ether;

Steps:

2.5 4.2.1.1 Synthesis of amino-acetonitrile hydrochlorides 2 and 3

General procedure: To a solution of chloroacetonitrile (1.1 equiv) in acetonitrile was added the primary amine (1 equiv), potassium carbonate (3 equiv) and sodium iodide (1 mol %). The reaction mixture was stirred at 80 °C for 18 h after which the precipitate was filtered and mother liquor concentrated in vacuo to yield a dark oil. The amino acetonitrile was dissolved in diethylether and treated with ethereal 1 N HCl (excess) to yield the hydrochloride salt, which was filtered and dried under vacuum to yield the desired product.

References:

Harker, Wesley R.R.;Delaney, Patrick M.;Simms, Michael;Tozer, Matthew J.;Harrity, Joseph P.A. [Tetrahedron,2013,vol. 69,# 5,p. 1546 - 1552]

50-00-0 Synthesis