N-(biphenyl-2-yl)-2-chloro-N-methylacetamide synthesis
- Product Name:N-(biphenyl-2-yl)-2-chloro-N-methylacetamide
- CAS Number:955879-95-5
- Molecular formula:C15H14ClNO
- Molecular Weight:259.73
14925-09-8
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Yield:955879-95-5 83%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 2 h;Cooling with ice;Inert atmosphere;
Steps:
N-(Biphenyl-2-yl)-2-chloro-N-methylacetamide (23)
In a perfectly dried two-necked flask, to a cooled (ice bath) solution of 22 in dry DCM (10 mL), N,N-diisopropylethylamine (1.5 eq.) and 2-chloroacetylchloride (1.5 eq.) were added. The solution was allowed to raise r.t. and stirred under a nitrogen streamfor 2 h and then HCl 0.5 N was added. The two phases were separated and the organic layer was driedover Na2SO4 and evaporated. The crude product was recrystallized from EtOH; Rf: 0.60(n-hexane/EtOAc 98:2); yield: 83%.
References:
Sozio, Piera;Marinelli, Lisa;Cacciatore, Ivana;Fontana, Antonella;Tuerkez, Hasan;Giorgioni, Gianfabio;Ambrosini, Dario;Barbato, Francesco;Grumetto, Lucia;Pacella, Stephanie;Cataldi, Amelia;Di Stefano, Antonio [Molecules,2013,vol. 18,# 9,p. 10747 - 10767]
![[1,1'-Biphenyl]-2-amine, N,N-dimethyl-](/CAS/20210305/GIF/6590-81-4.gif)
90-41-5
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