N-Boc-3-Methyl-5-nitroindazole synthesis
- Product Name:N-Boc-3-Methyl-5-nitroindazole
- CAS Number:599183-33-2
- Molecular formula:C13H15N3O4
- Molecular Weight:277.28
40621-84-9
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$19.00/100mg
24424-99-5
821 suppliers
$13.50/25G
599183-33-2
19 suppliers
$376.00/500mg
Yield:599183-33-2 85%
Reaction Conditions:
with dmap in dichloromethane at 20;
Steps:
4.1.8 General procedure for Boc protection (Procedure H)
General procedure: Di-tert-butyl dicarbonate (1.2 eq) was added to a solution of the corresponding amine (1.0 eq) and DMAP (1.1 eq) in CH2Cl2 at room temperature. The mixture was stirred overnight and then concentrated in vacuo. The residue was purified by silica gel column chromatography to obtain the desired product.
References:
Van Manh, Nguyen;Hoang, Van-Hai;Ngo, Van T.H.;Kang, Soosung;Jeong, Jin Ju;Ha, Hee-Jin;Kim, Hee;Kim, Young-Ho;Ann, Jihyae;Lee, Jeewoo [European Journal of Medicinal Chemistry,2022,vol. 244,art. no. 114837] Location in patent:supporting information
445-27-2
436 suppliers
$9.00/25g
599183-33-2
19 suppliers
$376.00/500mg
79110-05-7
159 suppliers
$20.00/5g
599183-33-2
19 suppliers
$376.00/500mg