ChemicalBook CAS DataBase List N-BOC-5-HYDROXYINDOLINE

N-BOC-5-HYDROXYINDOLINE synthesis

7synthesis methods

Product Name:N-BOC-5-HYDROXYINDOLINE
CAS Number:170147-76-9
Molecular formula:C13H17NO3
Molecular Weight:235.28

1H-Indole-1-carboxylic acid, 2,3-dihydro-5-(phenylmethoxy)-, 1,1-dimethylethyl ester

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Yield: 95%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 2 h;

Steps:

3.2 tert-butyl 5-hydroxyindoline-1-carboxylate
Compound 5- (benzyloxy) indoline-1-carboxylic acid tert-butyl ester 3a (2.42 g, 7.44 mmol) was dissolved in methanol (80 mL),Then 10% palladium on carbon (1.2 g) was added and stirred at room temperature under a hydrogen atmosphere for 2 hours.After the reaction was completed, the filtrate was filtered, and the solvent was removed under reduced pressure.The target product 5-hydroxyindoleline-1-carboxylic acid tert-butyl ester 3b (1.65 g, gray solid) was obtained,Yield: 95%.

References:

Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.;Bu Gonggaofamingren CN110483482, 2019, A Location in patent:Paragraph 0112; 0115; 0121-0125