ChemicalBook CAS DataBase List N-BOC-cis-4-fluoro-L-proline

N-BOC-cis-4-fluoro-L-proline synthesis

11synthesis methods

Product Name:N-BOC-cis-4-fluoro-L-proline
CAS Number:203866-13-1
Molecular formula:C10H16FNO4
Molecular Weight:233.24

203866-16-4 Synthesis

N-Boc-cis-4-Fluoro-L-proline methyl ester

203866-16-4
116 suppliers
$40.00/250mg

203866-13-1
220 suppliers
$6.00/250mg

Yield:203866-13-1 96%

Reaction Conditions:

Stage #1:1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate with water;lithium hydroxide in tetrahydrofuran at 0 - 20; for 2 h;
Stage #2: with hydrogenchloride in water; pH=5

Steps:

13.2 Step 2) the preparation of compound 13-3
To a solution of compound 13-2 (5.83 g, 23.58 mmol) in THF (30 mL) at 0 °C was added LiOH aqueous solution (1.98 g, 30 mL), and the mixture was stirred at rt for 2 hrs and adjusted to pH 5 with diluted hydrochloric acid (1 M). The solvent THF was removed in vacuo, and the aqueous layer was adjusted to pH 2 with diluted hydrochloric acid (1 M) and extracted with EtOAc (80 mL x 3). The combined organic layers were dried over Na₂S0₄ and concentrated in vacuo to give the title compound as a white solid (5.3 g, 96%). The compound was characterized by the following spectroscopic data: MS (ESI, pos.ion) m/z: 234.24 [M+H] ⁺; NMR (400 MHz, CDC1₃) δ (ppm): 8.76 (brs, 1 H), 5.28-5.12 (m, 1 H), 4.56-4.44 (m, 1H), 3.86-3.58 (m, 2H). 2.77-2.01 (m. 2H), 1.48-1.44 (d, 9H, J = 16 Hz).

References:

SUNSHINE LAKE PHARMA CO., LTD.;ZHANG, Yingjun;ZHANG, Jiancun;XIE, Hongming;REN, Qingyun;TAN, Yumei;LUO, Huichao WO2014/19344, 2014, A1 Location in patent:Paragraph 00435

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74844-91-0 Synthesis