N-BOC-(R)-1-AMINO-2-PROPANOL synthesis
- Product Name:N-BOC-(R)-1-AMINO-2-PROPANOL
- CAS Number:119768-44-4
- Molecular formula:C8H17NO3
- Molecular Weight:175.23
2799-16-8
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24424-99-5
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119768-44-4
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Yield:119768-44-4 100%
Reaction Conditions:
in dichloromethane at 0 - 20; for 2 h;Inert atmosphere;
Steps:
Intermediate 3 (1-3) (2i?-Hydroxy-propyl)-carbamic acid tert- vXy\ ester (1-3)
Intermediate 3 (1-3) (2i?-Hydroxy-propyl)-carbamic acid tert- vXy ester (1-3) Di-fert-butyl dicarbonate (58.1 g, 266.3 mmol) in DCM (50 mL) was added to a stirred solution of (i?)-(-)-l-amino-2-propanol in DCM (50 mL) at 0 °C under nitrogen. The mixture was stirred at rt for 2 h. The mixture was diluted with cooled water and extracted with DCM. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo to yield intermediate 1-3 as a colorless oil (47 g, quant.). The product was used in the next step without further purification.
References:
JANSSEN PHARMACEUTICA NV;VAN GOOL, Michiel, Luc, Maria;ALONSO-DE DIEGO, Sergio-Alvar;CID-NÚÑEZ, José, Maria;DELGADO-GONZÁLEZ, Óscar;DECORTE, Annelies, Marie, Antonius;MACDONALD, Gregor, James;MEGENS, Antonius, Adrianus, Hendrikus, Petrus;TRABANCO-SUÁREZ, Andrés, Avelino;GARCÍA-MOLINA, Aránzazu;ANDRÉS-GIL, José, Ignacio WO2014/195311, 2014, A1 Location in patent:Page/Page column 78
2799-16-8
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34619-03-9
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119768-44-4
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$13.00/1g
2592-18-9
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119768-44-4
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