N'-Cyano-3-nitrobenzenecarboximidamide synthesis
- Product Name:N'-Cyano-3-nitrobenzenecarboximidamide
- CAS Number:23275-42-5
- Molecular formula:C8H6N4O2
- Molecular Weight:190.16
619-24-9
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Yield:23275-42-5 95%
Reaction Conditions:
Stage #1: 3-nitrobenzonitrilewith sodium methylate in methanol at 20; for 4 h;
Stage #2: with CYANAMID in methanol at 20;
Steps:
A.A12.b
Example A12; b) Preparation of intermediate 38; [Show Image] Sodium methoxide (0.35 g, 0.0064 mol) was added to a solution of 1-cyano-3-nitrobenzene (9.48 g, 0.064 mol) in methanol (64 ml), and the resulting mixture was stirred at rt for 4 hours. Next, cyanamide (4.00 g, 0.096 mol) was added, and the mixture was stirred overnight at rt. Diethyl ether (200 ml) was then added. The resulting precipitate was filtered off, washed with ether and dried, yielding 11.53 g of intermediate 38 (white solid, yield: 95 %).
References:
EP1904461,2008,A2 Location in patent:Page/Page column 34
