ChemicalBook CAS DataBase List N-(Dibenzofuran-4-yl)acetamide

N-(Dibenzofuran-4-yl)acetamide synthesis

8synthesis methods

Product Name:N-(Dibenzofuran-4-yl)acetamide
CAS Number:50548-37-3
Molecular formula:C14H11NO2
Molecular Weight:225.24

60-35-5 Synthesis

60-35-5
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$13.00/25g

89827-45-2 Synthesis

89827-45-2
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$7.00/1g

50548-37-3
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Yield:50548-37-3 75%

Reaction Conditions:

with copper (I) iodide;potassium carbonate;N¹,N²-dimethylethane-1,2-diamine in 5,5-dimethyl-1,3-cyclohexadiene at 135; for 5 h;Inert atmosphere;

Steps:

1.1-1 Synthesis of Intermediate A-1

Under an argon atmosphere, a mixture of 1,200 g (4.86 mol) of 4-bromodibenzofuran, 573 g (9.71 mol) of acetamide, 184.98 g (971 mmol) of copper (I) iodide, 85.62 g (971 mmol) of N,N′-dimethylethylenediamine, 1,342 g (97.1 mol) of potassium carbonate, and 6 L of xylene was reacted at 135° C. for 5 h. After the reaction solution was cooled to room temperature, 4L of water was added thereto, followed by stirring for 1 h to precipitate crystals. And then the precipitated crystals were collected by filtration and washed with water and n-heptane to obtain 950 g of an intermediate A-1. The yield was 75%.

References:

US2020/317653,2020,A1 Location in patent:Paragraph 0265-0267