ChemicalBook CAS DataBase List n-ethyl-1-adamantanamin

n-ethyl-1-adamantanamin synthesis

5synthesis methods

Product Name:n-ethyl-1-adamantanamin
CAS Number:3717-44-0
Molecular formula:C12H21N
Molecular Weight:179.3

768-94-5
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$41.00/25g

56553-60-7 Synthesis

56553-60-7
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$10.00/5g

3717-44-0
14 suppliers
$285.00/500mg

Tricyclo[3.3.1.13,7]decan-1-amine, N,N-diethyl-

3788-37-2
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Yield:3788-37-2 73.4% ，3717-44-0 20.5%

Reaction Conditions:

in acetonitrile at 60; for 15 h;

Steps:

4. General Procedure of Experiment in Table 1.

General procedure: All reactions were carried out according to the procedure written below unless otherwise noted. The starting materials, aliphatic amines, (0.08 mmol) in dry acetonitrile (1.6 mL) was treated with NaBH(OAc)₃ (250 mg, 1.2 mmol) at 60 °C for 15 h. The reaction were worked up in the same manner as described in above section. Compound 7a: ¹H-NMR (500 MHz, CDCl₃) d 2.52 (4H, q, J = 7.2 Hz), 2.40 (2H, d, J = 7.8 Hz), 1.25 (32H, m), 1.02 (6H, t, J = 7.2 Hz), 0.88 (3H, t, J = 7.0 Hz); HRMS (ESI-TOF) m/z 326.3774 (Calcd for C₂₂H₄₈N 326.3781 [M+H]⁺).

References:

Tamura, Satoru;Sugawara, Aoi;Sato, Erika;Sato, Fuka;Sato, Keigo;Kawano, Tomikazu [Tetrahedron Letters,2020,vol. 61,# 22,art. no. 151919] Location in patent:supporting information