ChemicalBook CAS DataBase List N-Ethyl 4-fluorobenzamide

N-Ethyl 4-fluorobenzamide synthesis

9synthesis methods

Product Name:N-Ethyl 4-fluorobenzamide
CAS Number:772-18-9
Molecular formula:C9H10FNO
Molecular Weight:167.18

403-43-0
449 suppliers
$9.00/25g

75-04-7
378 suppliers
$10.00/20mg

772-18-9
25 suppliers
$55.00/250mg

Yield:772-18-9 100%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20;Inert atmosphere;

Steps:

10.B.10C

To a solution of ethylamine (69.4 mL, 139 mmol) and triethylamine (21.10 mL, 151 mmol) in DCM (Volume: 150 mL) was added p-Fluorobenzoyl chloride (15.13 mL, 126 mmol) at 0° C. The reaction was stirred at 0° C. for 1 hr and then warmed slowly to room temperature. The reaction mixture was diluted with water. The layers were separated and the organic layer was washed with brine, dried over MgSO4, filtered, and the organic phase stripped to dryness via rotary evaporation. The organic extract was dried in vacuo to provide N-ethyl-4-fluorobenzamide (21 g, 100% yield) as a tan solid.

References:

US2010/190763,2010,A1 Location in patent:Page/Page column 52

557-66-4 Synthesis