N-hydroxy-4-methoxybenzenecarboximidamide synthesis

Yield:1079393-88-6 67%

Reaction Conditions:

with ammonium hydroxide;sodium hydrogencarbonate in ethanol;water; for 3 h;Reflux;

Steps:

4.1.2.3 General procedure (C). Preparation of Phenyl amidoximes

General procedure: To a stirred solution of phenyl nitrile (0.1mol) in ethanol (100mL), a solution of hydroxylamine (0,6 mol) in H₂O (150mL) was slowly added followed by NaHCO₃ (0.3mol). The resulting mixture was refluxed for 3h. The solvent was evaporated in vacuo and the resulting residue was poured into cold water. The formed precipitate was filtered off, washed with water and dried in vacuo. The obtained product was recrystallized from methanol.

References:

Khanfar, Mohammad A.;Reiner, David;Hagenow, Stefanie;Stark, Holger [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 14,p. 4034 - 4046] Location in patent:supporting information