N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE synthesis

Yield:23530-48-5 96%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 4 h;

Steps:

13

To a stirred solution of isopropylamine (6.8 mL, 79.6 mmol) and triethylamine (16.6 mL, 119.4 mmol) in dichloromethane (300 mL) was added the solution of 4-nitro-benzenesulfonyl chloride (8.8 g, 39.8 mmol) in dichloromethane (50 mL) at 0° C. The mixture solution stirred at room temperature for 4 h. The mixture solution was stirred at room temperature for 4 h and then washed with brine (50 mL×2) and dried over anhydrous sodium sulfate. The solvent was removed in vacuo to afford N-isopropyl-4-nitro-benzenesulfonamide (9.3 g, 96%) as a white powder: MS (ESI) M+1=245.

References:

US2012/190677,2012,A1 Location in patent:Page/Page column 23-24