N-methoxy-N-methyl-1H-Indole-6-carboxamide synthesis
- Product Name:N-methoxy-N-methyl-1H-Indole-6-carboxamide
- CAS Number:394653-94-2
- Molecular formula:C11H12N2O2
- Molecular Weight:204.23
1670-82-2
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Yield:394653-94-2 85.9%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in N,N-dimethyl-formamide at 20; for 2 h;Inert atmosphere;Solvent;Reagent/catalyst;
Steps:
8.A Preparation of 6- (N-methoxy-N-methylformamide-1H-indole)
In a 250 mL three-necked flask, N, N-diisopropylethylamine (40 · 1 g, 310 · 3 mmo 1) and N, N-dimethylformamide (100 mL), slowly added dimethylhydroxylamine hydrochloride (18.2 g, 186.2 mmol) and HATU (47.2 g, 124 l), nitrogen Under the protection of 6-indole carboxylic acid (10.0g, 62. lmmo 1), room temperature reaction 2h, the reaction is completed, The reaction solution was poured into water to precipitate a solid, suction filtered and dried in vacuo to give 10.9 g of 6- (N-methoxy-N-methyl) formylamino-1H-indole in a yield of 85.9%
References:
CN106631970,2017,A Location in patent:Paragraph 0008; 0065-0067
6638-79-5
550 suppliers
$6.00/25g
394653-94-2
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