![](/CAS/GIF/885278-18-2.gif)
N-METHOXY-N-METHYL-THIAZOLE-2-CARBOXAMIDE synthesis
- Product Name:N-METHOXY-N-METHYL-THIAZOLE-2-CARBOXAMIDE
- CAS Number:885278-18-2
- Molecular formula:C6H8N2O2S
- Molecular Weight:172.2
![THIAZOLE-2-CARBOXYLIC ACID](/CAS/GIF/14190-59-1.gif)
14190-59-1
189 suppliers
$15.00/1g
![N,O-Dimethylhydroxylamine hydrochloride](/CAS/GIF/6638-79-5.gif)
6638-79-5
555 suppliers
$6.00/25g
![N-METHOXY-N-METHYL-THIAZOLE-2-CARBOXAMIDE](/CAS/GIF/885278-18-2.gif)
885278-18-2
16 suppliers
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Yield:885278-18-2 70%
Reaction Conditions:
Stage #1: 1,3-thiazole-2-carboxylic acidwith 2-chloro-4,6-dimethoxy-1 ,3,5-triazine in tetrahydrofuran at 0; for 0.25 h;
Stage #2: with 4-methyl-morpholine in tetrahydrofuran at 20; for 1.5 h;
Stage #3: N,O-dimethylhydroxylamine*hydrochloride in tetrahydrofuran at 0 - 20;
Steps:
1.1
Thiazole-2-carboxylic acid (5 g, 38.7 mmol) and CDMT (7.47 g, 42.6 mmol) were suspended in THF under N2 at O0C. After 15 min NMM (11.7 g, 12.76 mL, 116 mmol) was added dropwise. The reaction mixture was stirred for 1.5 hr at RT, and then N-
References:
WO2009/5460,2009,A1 Location in patent:Page/Page column 21-22