![](/CAS/GIF/147356-78-3.gif)
N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE synthesis
- Product Name:N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE
- CAS Number:147356-78-3
- Molecular formula:C6H11NO2
- Molecular Weight:129.16
![N,O-Dimethylhydroxylamine hydrochloride](/CAS/GIF/6638-79-5.gif)
6638-79-5
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![Cyclopropanecarboxylic acid](/CAS/GIF/1759-53-1.gif)
1759-53-1
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![N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE](/CAS/GIF/147356-78-3.gif)
147356-78-3
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$25.00/1g
Yield:-
Reaction Conditions:
with triethylamine;1,1'-carbonyldiimidazole in dichloromethane at 25;
Steps:
B.1
Step l Into a 10-L 4-necked round-bottom flask were placed a solution of cyclopropanecarboxylic acid (500 g, 5.81 mol) in dichloromethane (5000 mL), methoxy(methyl)amine hydrochloride (620 g, 6.36 mol), TEA (1761 g, 17.40 mol), and CDI (1 130 g, 6.97 mol). The resulting solution was stirred overnight at room temperature. The mixture was then diluted with 5000 mL of water and extracted with 2x2000 mL of dichloromethane. The combined organic layers were washed with 2000 mL of brine, dried over anhydrous sodium sulfate, and concentrated under vacuum to afford B2.
References:
MERCK SHARP & DOHME CORP.;DAI, Xing;CUMMING, Jared, N.;LIU, Hong;SCOTT, Jack, D. WO2016/85780, 2016, A1 Location in patent:Page/Page column 48
![N,O-Dimethylhydroxylamine hydrochloride](/CAS/GIF/6638-79-5.gif)
6638-79-5
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$6.00/25g
![Cyclopropanecarbonyl Chloride](/CAS/GIF/4023-34-1.gif)
4023-34-1
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![N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE](/CAS/GIF/147356-78-3.gif)
147356-78-3
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$25.00/1g
![1-chlorocyclopropane-1-carboxylic acid](/CAS/20180703/GIF/108817-35-2.gif)
108817-35-2
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![N,O-Dimethylhydroxylamine hydrochloride](/CAS/GIF/6638-79-5.gif)
6638-79-5
555 suppliers
$6.00/25g
![N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE](/CAS/GIF/147356-78-3.gif)
147356-78-3
86 suppliers
$25.00/1g
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1000210-73-0
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![N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE](/CAS/GIF/147356-78-3.gif)
147356-78-3
86 suppliers
$25.00/1g