N-Methyl-1-(phenylmethyl)-3-piperidinamine synthesis
- Product Name:N-Methyl-1-(phenylmethyl)-3-piperidinamine
- CAS Number:60717-45-5
- Molecular formula:C13H20N2
- Molecular Weight:204.31
40114-49-6
170 suppliers
$90.00/10g
74-89-5
7 suppliers
$13.44/25ML
60717-45-5
18 suppliers
$155.00/50mg
Yield:-
Reaction Conditions:
with sodium tris(acetoxy)borohydride in tetrahydrofuran;dichloromethane at 20;
Steps:
24.1 Step 1: 1-benzyl-N-methylpiperidin-3-amine
To a solution of 1-benzylpiperidin-3-one (1.0 g, 5.3 mmol) in dichloromethane (25 mL) was added a solution of methylamine in tetrahydrofuran (5.3 mL, 2 M, 10.6 mmol). The mixture was stirred at room temperature for 5 minutes then NaBH(OAc)3 (2.2 g, 10.6 mmol) was added to the solution. The mixture was stirred at room temperature overnight then washed with saturated aqueous NaHCO3 solution, dried and concentrated under vacuum to give 1- benzyl-N-methylpiperidin-3-amine (1.0 g, crude). LCMS m/z = 205.1 [M+H]+.
References:
WO2017/216726,2017,A1 Location in patent:Page/Page column 565
40114-49-6
170 suppliers
$90.00/10g
593-51-1
533 suppliers
$21.00/100g
60717-45-5
18 suppliers
$155.00/50mg
40114-49-6
170 suppliers
$90.00/10g
60717-45-5
18 suppliers
$155.00/50mg