![](/CAS/20150408/GIF/1154383-52-4.gif)
N-Methylpyrazole-4-carboxaMide synthesis
- Product Name:N-Methylpyrazole-4-carboxaMide
- CAS Number:1154383-52-4
- Molecular formula:C5H7N3O
- Molecular Weight:125.13
![Ethyl pyrazole-4-carboxylate](/CAS/GIF/37622-90-5.gif)
37622-90-5
337 suppliers
$6.00/1g
![Methylamine](/CAS/GIF/74-89-5.gif)
74-89-5
7 suppliers
$13.44/25ML
![N-Methylpyrazole-4-carboxaMide](/CAS/20150408/GIF/1154383-52-4.gif)
1154383-52-4
62 suppliers
$20.00/250mg
Yield: 100%
Reaction Conditions:
in water at 50 - 55; for 4 h;Inert atmosphere;
Steps:
9.5 Step 5
Ester 4ε (695 g, 4.96 mol, 1.0 eq.) was added into 40 wt Me fc in water (3.5 L, 5 vol.) under a N2 atmosphere. The suspension was heated to 50-55 °C for 3-4 h and gradually dissolved. The reaction was monitored by HPLC (HPLC showed 4c was consumed completely by HPLC). Water was removed by distillation at 65 °C. PhMe (3.5 L x 2) was added into the solid and the water was removed by distillation at 65 °C. 620 g of 4d was obtained as an off-white solid with 97 A% HPLC purity in quantity yield.
References:
EPIZYME, INC.;CAMPBELL, John Emmerson;DUNCAN, Kenneth William;MILLS, James Edward John;MUNCHHOF, Michael John WO2019/79540, 2019, A1 Location in patent:Paragraph 01615