N-methylthiophene-2-sulfonamide synthesis
- Product Name:N-methylthiophene-2-sulfonamide
- CAS Number:53442-30-1
- Molecular formula:C5H7NO2S2
- Molecular Weight:177.24
16629-19-9
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74-89-5
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53442-30-1
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Yield:53442-30-1 100%
Reaction Conditions:
in tetrahydrofuran;ethanol at 20; for 2 h;
Steps:
26.a
a) /V-methylthiophene-2-sulfonamideMeNH2 (10.3 ml_, 8 M solution in EtOH, 82.12 mmol) was added to a solution of 2-thiophenesulfonyl chloride (5.0 g, 27.37 mmol) in THF (70 ml_). The reaction mixture was stirred at r.t. for 2 h, poured into H2O (100 ml_) and extracted with CH2CI2 (2x100 ml_). The organic layer was dried over Na2SO4 (anhydrous), filtered and concentrated, to give 5.05 g of /V-methylthiophene- 2-sulfonamide, that were submitted to next step without purification (brown- coloured solid, yield: quantitative). 1H NMR (CDCI3, 250 MHz) δ ppm: 7.60 (m, 2H), 7.09 (dd, J = 3.7 Hz, 4.0 Hz, 1 H), 4.88 (bs, 1 H), 2.71 (s, 3H).
References:
WO2009/80722,2009,A2 Location in patent:Page/Page column 44
67-56-1
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6339-87-3
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53442-30-1
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$45.00/25mg
6339-87-3
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80-43-3
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53442-30-1
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