N,N-bis(2-chloroethyl)-4-nitro-benzenesulfonamide synthesis
- Product Name:N,N-bis(2-chloroethyl)-4-nitro-benzenesulfonamide
- CAS Number:90876-33-8
- Molecular formula:C10H12Cl2N2O4S
- Molecular Weight:327.18
18226-07-8
3 suppliers
inquiry
90876-33-8
11 suppliers
inquiry
Yield:90876-33-8 95%
Reaction Conditions:
with thionyl chloride at 110; for 1 h;
Steps:
2.S2
S2: In a fitted with a mechanical stirrer,thermometer,Constant pressure dropping funnel 2L dry four-necked flask was added 435g(1.5 mol, 1.0 eq) of N, N-bis (2-hydroxyethyl) p-nitrobenzenesulfonamide and 500 mL of thionyl chloride,Heated to 110 degrees reflux for 1 hour,Distilled to remove excess thionyl chloride,Cool to room temperature,To the residue was added 1 L of ice water,The resulting solid was filtered,The crude product is recrystallized from 500 mL of methanol,Filtered to give a white solid,dry,Weighing,466 g of N, N-bis (2-chloroethyl) p-nitrobenzenesulfonamide are obtained,Yield 95%Purity 99% (HPLC).
References:
CN106588925,2017,A Location in patent:Paragraph 0039
98-74-8
156 suppliers
$10.00/5g
90876-33-8
11 suppliers
inquiry
