N,N'-BIS(5-METHYLPYRIDIN-2-YL)UREA synthesis

Yield:63272-29-7 88%

Reaction Conditions:

with sodium carbonate;titanium(IV) oxide for 12 h;Irradiation;

Steps:

7 Example 7

34.90 parts of tetrabromomethane (content of 97.0%) were added to the reactor containing 85.00 parts of trifluorotoluene, 21.85 parts of 2-amino-5-methylpyridine (content of 99.0%) were added,Then add 0.29 parts of titanium dioxide (99.0%) and 32.85 parts of sodium carbonate (content 99.8%),Under the xenon lamp as the light source, after stirring and reacting for 12 hours, let it stand for stratification.The upper layer is a colorless liquid, and the lower layer is a red-black oily bromine element. The upper solution is distilled to recover the toluene solvent to obtain a white 1,3-bis(5-methylpyridine)-2-ylurea solid product.

References:

CN112920140,2021,A Location in patent:Paragraph 0066-0069; 0079