![](/CAS/20180629/GIF/1076224-00-4.gif)
N-(N-BOC-Piperidino)pyrazole-4-carboxaldehyde synthesis
- Product Name:N-(N-BOC-Piperidino)pyrazole-4-carboxaldehyde
- CAS Number:1076224-00-4
- Molecular formula:C14H21N3O3
- Molecular Weight:279.33
![1H-Pyrazole-4-carboxaldehyde](/CAS/GIF/35344-95-7.gif)
35344-95-7
186 suppliers
$32.00/1g
![1-Boc-4-methanesulfonyloxypiperidine](/CAS/GIF/141699-59-4.gif)
141699-59-4
232 suppliers
$6.00/1g
![N-(N-BOC-Piperidino)pyrazole-4-carboxaldehyde](/CAS/20180629/GIF/1076224-00-4.gif)
1076224-00-4
18 suppliers
$115.00/50mg
Yield:1076224-00-4 1.2 g
Reaction Conditions:
with Cs2CO3 in N,N-dimethyl-formamide at 80;
Steps:
2 Step 2. Preparation of Intermediate Z-3-2
To a solution of intermediate Z-3-1 (3.07 g, 10.99 mmol) and 1H-pyrazole-4-carbaldehyde (960 mg, 9.99 mmol) in DMF (50 mL) was added Cs2CO3 (8.14 g, 24.98 mmol),The mixture was warmed to 80°C and stirred overnight.After the reaction was completed, it was cooled to room temperature, extracted with EA/H 2 O, and the combined organic phases were dried over anhydrous sodium sulfate,After filtration, the crude product obtained by concentration was separated and purified by silica gel column to obtain intermediate Z-3-2 (1.2 g, 4.30 mmol, 43.00% yield)
References:
WO2022/184130,2022,A1 Location in patent:Page/Page column 23; 24
![N-BOC-4-Hydroxypiperidine](/CAS/GIF/109384-19-2.gif)
109384-19-2
470 suppliers
$5.00/1g
![N-(N-BOC-Piperidino)pyrazole-4-carboxaldehyde](/CAS/20180629/GIF/1076224-00-4.gif)
1076224-00-4
18 suppliers
$115.00/50mg
![tert-butyl 4-(4-(ethoxycarbonyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate](/CAS/20130318/GIF/CB22589541.gif)
782493-64-5
17 suppliers
inquiry
![N-(N-BOC-Piperidino)pyrazole-4-carboxaldehyde](/CAS/20180629/GIF/1076224-00-4.gif)
1076224-00-4
18 suppliers
$115.00/50mg