ChemicalBook CAS DataBase List N-n-Butyl benzene sulfonamide

N-n-Butyl benzene sulfonamide synthesis

12synthesis methods

Product Name:N-n-Butyl benzene sulfonamide
CAS Number:3622-84-2
Molecular formula:C10H15NO2S
Molecular Weight:213.3

109-73-9 Synthesis

109-73-9
439 suppliers
$9.00/1g

98-09-9
339 suppliers
$12.00/25 g

3622-84-2
307 suppliers
$16.00/25g

Yield:3622-84-2 99%

Reaction Conditions:

with sodium hydroxide in water at 20; for 1.5 h;Reagent/catalyst;

Steps:

1-10 Example 1
A method for synthesizing N-butylbenzenesulfonamide, the method comprising the steps of:Step 1. In a four-necked flask equipped with a stirrer, a temperature measuring jacket, a nitrogen tube, and a vertical condenser,Adding 5 g of a silica-alumina composite porous catalyst and 120 ml of an aqueous solution of 20% sodium hydroxide, and purging with nitrogen for 10 min;Step 2. Slowly add 1 mol of phenylsulfonyl chloride and 3 mol of n-butylamine to the flask within 1 h.Under ultrasonic conditions, the temperature was kept at 20 ° C for 30 min.Subsequently, the temperature is raised to 60 ° C to precipitate, to obtain an organic phase of N-butylbenzenesulfonamide;Step 3. Maintain a bottom temperature of 140 ° C under a vacuum of 98 Kpa.The organic phase was distilled for 1 h to remove water and n-butylamine;Step 4. Distilling under vacuum at a pressure of 0.07 Kpa to obtain a residue.The high purity product N-butylbenzenesulfonamide contained in the organic phase was collected at the end of the distillation.

References:

Nantong Wolan Chemical Co., Ltd.;Sun Qiang;Wu Jianguo;Wan Haibing CN109369473, 2019, A Location in patent:Paragraph 0007; 0009-0028

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