N,N-dimethyl-1H-benzoimidazol-2-amine synthesis

9synthesis methods

Product Name:N,N-dimethyl-1H-benzoimidazol-2-amine
CAS Number:2851-13-0
Molecular formula:C9H11N3
Molecular Weight:161.2

4857-06-1 Synthesis

4857-06-1
279 suppliers
$6.00/1g

124-40-3
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$18.00/100ml

2851-13-0
28 suppliers
$87.00/250mg

Yield:2851-13-0 89%

Reaction Conditions:

in water;N,N-dimethyl-formamide at 200; for 0.5 h;

Steps:

4F.1

Commercially available 2-chloro-1H-benzo[d]imidazole (250 mg, 1.64 mmol) was dissolved in DMF (4.7 mL), dimethylamine (50% aqueous solution, 0.50 mL, 4.92 mmol) was added, and the mixture was stirred with heating at 200°C for 30 min in an Emrys Optimizer microwave synthesizer. Water was added to the mixture, and the precipitated crystals were collected by suction filtration to give N,N-dimethyl-1H-benzo[d]imidazole-2-amine (234 mg, 89%). ESIMS m/z: 162 (M + H)⁺; ¹H NMR (270 MHz, DMSO-d₆, δ): 3.03 (s, 6H), 6.79-6.97 (m, 2H), 7.07-7.20 (m, 2H), 11.17 (br s, 1H)

References:

EP2740730,2014,A1 Location in patent:Paragraph 0320

95-54-5 Synthesis