N,N-dimethyl-2-nitrobenzenesulfonamide synthesis
- Product Name:N,N-dimethyl-2-nitrobenzenesulfonamide
- CAS Number:23530-43-0
- Molecular formula:C8H10N2O4S
- Molecular Weight:230.24
1694-92-4
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Yield:23530-43-0 96%
Reaction Conditions:
in tetrahydrofuran at 0 - 50;
Steps:
33 2-nitro-(N,N-dimethyl)phenylsulphonamide
DIMETHYLAMINE] (2M in THF) (5.64mL, 11. [3MMOL)] was added to a screw cap vial and THF was added (2mL). The solution was cooled to [0°C] and to it was added 2-nitrobenzenesulphonyl chloride (500mg, 2. [26MMOL)] in THF [(1ML).] The resultant mixture was stirred at room temperature for four hours and then left stirring at [50°C] overnight. The reaction was then allowed to cool to room temperature. The reaction was concentrated and the residue was dissolved in [CH2CI2] and was sequentially washed with water, [1N NAOH,] water and brine. The organic phase was dried over [MGS04,] filtered and concentrated. The crude product was purified by an SPE tube using Hexanes: EtOAc (90: 10 to 20: 80) to yield the title compound as a yellow solid (498.4mg, 96%).
References:
WO2004/22534,2004,A1 Location in patent:Page 101; 102
