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ChemicalBook CAS DataBase List N,O3'-dibenzoylgeMcitabine

N,O3'-dibenzoylgeMcitabine synthesis

6synthesis methods
N-Benzoyl-2'-deoxy-5'-O-[(1,1-diMethylethyl)diMethylsilyl]-2',2'-difluorocytidine 3'-Benzoate

1151528-37-8
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N,O3'-dibenzoylgeMcitabine

1020657-43-5
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Yield:1020657-43-5 85%

Reaction Conditions:

Stage #1: C29H33F2N3O6Siwith tetrabutyl ammonium fluoride in tetrahydrofuran at 0; for 3.5 h;
Stage #2: with acetic acid

References:

Labroli, Marc A.;Dwyer, Michael P.;Shen, Ruichao;Popovici-Muller, Janeta;Pu, Qinglin;Richard, Judson;Rosner, Kristen;Paruch, Kamil;Guzi, Timothy J. [Tetrahedron Letters,2014,vol. 55,# 3,p. 598 - 602]