n-Propyl 4-Hydroxybenzoate--d4 synthesis

Yield:1219802-67-1 72.1%

Reaction Conditions:

with toluene-4-sulfonic acid at 80; for 12 h;

Steps:

7 Example 7

In a magnetic stirrer,Thermometer and reflux condenser in a three-necked flask,7.1 g of p-hydroxybenzoic acid-D4 (0.05 mol) was added,23.4 mL isopropanol,4.13 g p-toluenesulfonic acid,Heating up to 80 ,Stirring state,Insulation reaction for 12 hours;After the reaction,Cooled to room temperature,Filter,The filtrate was adjusted to pH = 7 to 8 with 10% NaOH solution,Filter,Vacuum drying oven 50 dry to constant weight,To give 6.63 g of a white powder,The yield of p-hydroxybenzoic acid-D4 was 72.1%The chemical purity of methyl p-hydroxybenzoate-D4 was 99.05%Isotope abundance 99.20atom% D.

References:

CN106365987,2017,A Location in patent:Paragraph 0046; 0047