N-Thiazol-2-yl-forMaMide synthesis

9synthesis methods

Product Name:N-Thiazol-2-yl-forMaMide
CAS Number:25602-39-5
Molecular formula:C4H4N2OS
Molecular Weight:128.15

96-50-4 Synthesis

96-50-4
513 suppliers
$5.00/5g

109-94-4 Synthesis

109-94-4
464 suppliers
$10.00/10g

25602-39-5
13 suppliers
$45.00/50mg

Yield:25602-39-5 88%

Reaction Conditions:

with N¹-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine-sulfamic acid supported on mesoporous silica SBA-15 in neat (no solvent) at 50;Green chemistry;

Steps:

General procedure for N-formylation

General procedure: To a mixture of aniline (1 mmol) and ethyl formate (1.5 mmol),1 mol% of SBA-15/PrEn-NHSO₃H was added and the mixture was stirred at 50^°C under solvent free condition. The progress of the reaction was monitored by TLC. After completion of the reaction,ethyl acetate was added to the solidified mixture and the solid catalyst was separated by filtration. The filtrate was dried over anhydrous Na₂SO₄. The solvent was evaporated and the product,obtained, was subjected to column chromatography. The isolated catalyst could be reused by addition of new portions of substrate.The structure of products obtained had been confirmed by physical properties such as ¹H NMR. ¹H NMR (300.13 MHz, CHCl₃): 7.40(s,CHO), 7.74(d, J 8.7 Hz, H-Ar), 8.24(d, J 8.7 Hz, H-Ar), 8.49(NH).

References:

Rostamnia, Sadegh;Doustkhah, Esmail [Journal of Molecular Catalysis A: Chemical,2016,vol. 411,p. 317 - 324]

96-50-4 Synthesis

96-50-4
513 suppliers
$5.00/5g

64-18-6 Synthesis