N2-(1-Benzylpiperidin-4-yl)pyridine-2,3-diaMine synthesis
- Product Name:N2-(1-Benzylpiperidin-4-yl)pyridine-2,3-diaMine
- CAS Number:185058-55-3
- Molecular formula:C17H22N4
- Molecular Weight:282.38
185058-54-2
14 suppliers
inquiry
185058-55-3
6 suppliers
inquiry
Yield:-
Reaction Conditions:
with hydrogenchloride;stannous chloride in tetrahydrofuran;ethyl acetate;
Steps:
99.B Step B
Step B 2-N-(1-Benzyl-piperidin-4-yl)-pyridine-2,3-diamine To a solution of (1-Benzyl-piperidin-4-yl)-(3-nitro-pyridin-2-yl)-amine (from Step A) in 10 mL of THF was added 2.4 g of SnCl2 and 1 mL of concentrated HCl at room temperature, stirred at room temperature for 2 hours. The reaction was diluted with 40 mL of EtOAc and washed with 30 mL of saturated NaHCO3 aqueous solution. After separating layers, the aqueous phase was extracted with 2*15 mL EtOAc. The combined organic phases were washed with 15 mL of brine, dried over MgSO4 and concentrated under reduced pressure to give 603 mg of yellow soid.
References:
US6248755,2001,B1
5470-18-8
432 suppliers
$6.00/5g
185058-55-3
6 suppliers
inquiry