N4-(4-methoxybenzyl)-2-chloropyridine-3,4-diamine synthesis

5synthesis methods

Product Name:N4-(4-methoxybenzyl)-2-chloropyridine-3,4-diamine
CAS Number:881844-10-6
Molecular formula:C13H14ClN3O
Molecular Weight:263.72

881844-09-3 Synthesis

N-(4-methoxybenzyl)-2-chloro-3-nitropyridin-4-amine

881844-09-3
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N4-(4-methoxybenzyl)-2-chloropyridine-3,4-diamine

881844-10-6
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Yield:881844-10-6 83%

Reaction Conditions:

with iron;ammonium chloride in ethanol;water; for 6 h;Reflux;

References:

Horatscheck, André;Andrijevic, Ana;Nchinda, Aloysius T.;Le Manach, Claire;Paquet, Tanya;Khonde, Lutete Peguy;Dam, Jean;Pawar, Kailash;Taylor, Dale;Lawrence, Nina;Brunschwig, Christel;Gibhard, Liezl;Njoroge, Mathew;Reader, Janette;Van Der Watt, Mari?tte;Wicht, Kathryn;De Sousa, Ana Carolina C.;Okombo, John;Maepa, Keletso;Egan, Timothy J.;Birkholtz, Lyn-Marie;Basarab, Gregory S.;Wittlin, Sergio;Fish, Paul V.;Street, Leslie J.;Duffy, James;Chibale, Kelly [Journal of Medicinal Chemistry,2020,vol. 63,# 21,p. 13013 - 13030] Location in patent:supporting information

881844-09-3 Synthesis

881844-09-3
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