ChemicalBook CAS DataBase List nalbuphine

nalbuphine synthesis

14synthesis methods

Product Name:nalbuphine
CAS Number:20594-83-6
Molecular formula:C21H27NO4
Molecular Weight:357.45

23277-43-2 Synthesis

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Yield: 97%

Reaction Conditions:

with hydrogenchloride;potassium carbonate;sodium chloride in water; pH=9.3

Steps:

1
Nalbuphine hydrochloride dihydrate (600 mg, from Sigma) was dissolved in water (100 mL). Saturated aqueous K₂CO₃ was added and then adjusted the pH to 9.3 with 1 N HCl solution, saturated with sodium chloride. The solution was extracted with dichloromethane (5 x 25 mL). The combined organic solution was washed with brine (100 mL), dried over Na₂SO₄, concentrated to dryness and dried under high vacuum to yield nalbuphine (483.4 mg, 97% recovery). The product was confirmed by ¹H-NMR in CDCl₃.

References:

Location in patent:Page/Page column 42