Naphthalene, 2-(2,2,2-trifluoroethyl)- synthesis
8synthesis methods
- Product Name:Naphthalene, 2-(2,2,2-trifluoroethyl)-
- CAS Number:1204295-99-7
- Molecular formula:C12H9F3
- Molecular Weight:210.2
Yield:1204295-99-7 90%
Reaction Conditions:
Stage #1: 1,1,1-trifluoro-2-iodoethane;naphthalene-2-boronic acidwith tris(dibenzylideneacetone)dipalladium(0) chloroform complex;caesium carbonate;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene in 1,4-dioxane at 20; for 0.0166667 h;Inert atmosphere;
Stage #2: with water in 1,4-dioxane at 80; for 12 h;Inert atmosphere;
References:
Zhao, Yanchuan;Hu, Jinbo [Angewandte Chemie - International Edition,2012,vol. 51,# 4,p. 1033 - 1036] Location in patent:supporting information; experimental part
