Naproxen sodium synthesis
- Product Name:Naproxen sodium
- CAS Number:26159-34-2
- Molecular formula:C14H13O3.Na
- Molecular Weight:252.24
22204-53-1
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26159-34-2
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Yield:-
Reaction Conditions:
in methanol;
Steps:
26 EXAMPLE 26
EXAMPLE 26 This example illustrates the conversion of free carboxylic acid of Example 1-25 to various salts. To a solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)-propionic acid in 5 ml of methanol is added a 1 molar equivalent of sodium hydroxide, in the form of a 0.1N solution. The solvent is evaporated in vacuo and the residue is taken up in 2 ml of methanol, followed by precipitation with ether, to yield crude sodium (S)-2-(6-methoxy-2-naphthyl)propionate. Likewise, other salts, e.g., ammonium and potassium (S)-2-(6-methoxy-2-naphthyl)propionate, are prepared by substituting ammonium hydroxide and potassium hydroxide for sodium hydroxide.
References:
US4723033,1988,A
23981-80-8
163 suppliers
$8.00/1g
26159-34-2
387 suppliers
$5.00/10mg