Nicotinic Acid-d1 synthesis
- Product Name:Nicotinic Acid-d1
- CAS Number:116975-14-5
- Molecular formula:C6H4DNO2
- Molecular Weight:124.1156
59-67-6
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Yield:116975-14-5 45%
Reaction Conditions:
Stage #1: nicotinic acidwith 2,2,6,6-tetramethyl-piperidine;n-butyllithium in tetrahydrofuran;hexane at -50; for 0.5 h;Metallation;
Stage #2: with water-d2 in tetrahydrofuran;hexane;Substitution;
References:
Mongin, Florence;Trecourt, Francois;Queguiner, Guy [Tetrahedron Letters,1999,vol. 40,# 30,p. 5483 - 5486]