![](/CAS/GIF/609-32-5.gif)
NITROMALONALDEHYDE synthesis
- Product Name:NITROMALONALDEHYDE
- CAS Number:609-32-5
- Molecular formula:C3H3NO4
- Molecular Weight:117.06
![2,3-dibromo-4-oxo-but-2-enoic acid](/CAS/GIF/21577-50-4.gif)
21577-50-4
19 suppliers
$75.00/2.5g
![NITROMALONALDEHYDE](/CAS/GIF/609-32-5.gif)
609-32-5
32 suppliers
inquiry
Yield: 99%
Reaction Conditions:
with sodium nitrite in ethanol;water at 0 - 60;
Steps:
B2.164.I Step-I: 2-Nitromalonaldehyde (intermediate B2-1)
Step-I: 2-Nitromalonaldehyde (intermediate B2-1) CHO OzN ^^CHO [00232] To a solution of 2,3-dibromo-4-oxobut-2-enoic acid (20 g, 78 mmol) in ethanol (30 mL), was added a solution of sodium nitrate (20 g, 235 mmol) in water (30.0 mL) at 0 °C. The reaction mixture was allowed to stir at 60 °C for 30 min. Then the reaction mixture was allowed to stir at room temperature for 1 h. The reaction mixture was cooled to 0 °C, at which point the solid was precipitated. The precipitated solid was filtered off and dried to afford the title compound as a yellowish solid (9.0 g, 99.0%). MS(ES): m/z 116.2 [M-H]".
References:
BRISTOL-MYERS SQUIBB COMPANY;WASHBURN, William N.;MURUGAIAH SUBBAIAH, Murugaiah Andappan;AHMAD, Saleem WO2014/39412, 2014, A1 Location in patent:Paragraph 00232