NOA 407854 synthesis
- Product Name:NOA 407854
- CAS Number:314020-44-5
- Molecular formula:C18H24N2O3
- Molecular Weight:316.39
Yield:314020-44-5 90%
Reaction Conditions:
with triethylamine in 5,5-dimethyl-1,3-cyclohexadiene;Reflux;
Steps:
7 Example 7:8-(2,6-Diethyl-4-methylphenyl)tetrahydropyrazolo[1,2-d][1,4,5]oxathiazepine-7,9-dioneSynthesis
Adding to the xylene solution of [1,4,5]-oxadiazepane prepared in the third embodiment4-(2,6-Diethyl-4-methylphenyl)malonamide 49.7 g (0.20 mol),Triethylamine 30.4 g (0.30 mol). The reaction solution was heated to reflux.After the reaction is completed, it is cooled to room temperature, and the reaction liquid is sequentially treated with 1N hydrochloric acid.Washed with water, dried,Concentration to give the solid 8-(2,6-diethyl-4-methylphenyl)tetrahydropyrazolo[1,2-d][1,4,5]oxadiazepane-7,9 -dione 56.9g,The yield was 90%.
References:
CN108264492,2018,A Location in patent:Paragraph 0035; 0036
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