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61425-17-0

Nocardicin D synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: MeOH/H2O, reflux, 3 d
2: pyridine / 7 °C
3: 1.) NaN3; 2.) N2O4, NaOAc / 1.) DMSO, 50 degC, overnight, 2.) CHCl3, O degC, 1 h, room temp., 2 h
4: DBU / CH2Cl2 / 0.02 h / Ambient temperature
5: 100 percent / H2, NaHCO3 / Pd-C / H2O; ethyl acetate / 1 h

References:

Isenring;Hofheinz [Tetrahedron,1983,vol. 39,# 15,p. 2591 - 2597]

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